Anxiety, depression, and the development of Alzheimer’s disease – what was the effect of COVID-19 lockdown?


  • Increased anxiety and depression during COVID-19 confinement are associated with increased neuroinflammation, especially in women.

Why this matters

  • Anxiety and depression have increased in recent years in line with the COVID-19 pandemic and increased home confinement/isolation, especially among women.

  • Studies indicate that there may be a reciprocal relationship between anxiety, depression, and Alzheimer’s disease (AD) with an increase in one increasing the risk of the other.

  • Understanding what role COVID-19-related confinement played in the mental health of individuals at risk for cognitive decline will further understanding of the role of neuropsychiatry and the development of AD.