Older individuals with low values for systolic blood pressure, BMI, or non-high-density lipoprotein (HDL) cholesterol have a higher dementia risk compared to individuals without any low values. Dementia risk is substantially higher in individuals with low values for all three risk factors.
Why this matters
U-shaped associations have been described between a variety of cardiovascular risk factors and dementia in late life. The exact nature of these associations, and whether these risk factors have an additive effect remain unclear.
Observing these risk factors could help clinicians to identify older individuals at increased risk for cognitive decline and dementia. This may contribute to developing new prediction models and future guidelines.