Focal cortical dysplasia in sensorimotor neural networks associated with earliest age of epilepsy onset


  • Focal cortical dysplasia co-localization to distributed functional networks is related to age of epilepsy onset, with earliest in sensory neural networks and latest in the limbic network.

Why this matters?

  • Although focal cortical dysplasia is the most common cause of pharmacoresistant epilepsy in children, predictors of age of epilepsy onset are unknown.

  • The findings reported here provide a potential biologic basis for the developmental differences in the variable age of epilepsy onset seen in children with focal cortical dysplasia-related epilepsy and further our understanding of focal epilepsy as a network disorder, which could ultimately improve treatment of pharmacoresistant epilepsy.