The disruptive role of white matter lesion burden in the integrity of the cholinergic system

Takeaway

  • In cognitively unimpaired older individuals, white matter lesion burden plays a central role in the degeneration of cholinergic pathways.

Why this matters

  • Several pathological processes might contribute to the degeneration of the cholinergic system in aging, including white matter lesions. However, how they may influence cognitive performance is unclear.

  • These findings may aid the development of prevention programs for neurodegeneration and cognitive impairment, eventually guiding therapeutic decisions.