Weight changes in newly diagnosed patients with Parkinson’s disease have varying implications for cognition

Takeaway

  • In patients newly diagnosed with Parkinson’s disease (PD), weight loss is associated with a faster decline in executive function and global cognition, whilst weight gain is linked to slower decline in attention and speed of processing.

Why this matters

  • PD is a common neurodegenerative disorder that is characterized by motor and non-motor symptoms.  

  • Weight change has been associated with dementia in older individuals; however, any association in patients with PD is unclear.

  • Understanding the associations of weight changes with cognition in PD might allow clinicians to intervene earlier to support weight management to protect or rehabilitate cognitive function.